Endocrine Abstracts

67 y/o old female, with long history of hyperthyroidism, without treatment and hypertension. Two months prior to admission, she received amiodarone 200 mg daily due to cardiac arrhythmia. One week prior to admission, she developed symptoms of Congestive Heart Failure and weight loss. Family history: hyperthyroidism in two sisters. Physical examination: acutely ill, thin female, in moderate respiratory distress. Alert, oriented x 3.BP: 155/119 mmHg HR: 150.Prominent findings: m...

Introduction: The use of radioiodine is a common treatment for differentiated thyroid cancer. However, special care should be exercised in treating patients who are on hemodialysis, due to the renal elimination of the radionuclide, which implies several technical difficulties and safety concerns. We have previously described the procedure and the short-term outcome and safety in three patients (Jimenez et al, Thyroid 2001; 11(11):1031–1034). Our results showed that the ra...

IGFBP-5 is the most conserved of a family of high affinity proteins that modulate IGF activity. It is upregulated in key lineages during their differentiation and development. In addition to domains associated with IGF binding, IGFBP-5 also possesses motifs that may be involved with its recently demonstrated IGF-independent actions. We have therefore examined the hypothesis that IGFBP-5 is important during development. We have generated mice overexpressing IGFBP-5 using an ear...

51 y/o female with past medical history of migraine headache, brought to UR because of hypoactivity, generalized weakness, confusion, lack of balance and dysarthria since one day of evolution. No medications. No Habits. Past history: negative for hypertension, cardiac disease or dyslipidemia. Physical examination: normal vital signs and weight. Alert, awake, and oriented only in person. Palpable nontender left thyroid lobe. Bilateral hyperreflexia.Labs: ...

A 49 years old male patient with 12 years history of poorly controlled type 2 diabetes mellitus on insulin therapy, complicated with neuropathy, nephropathy, retinopathy, peripheral arterial disease (right toe amputation), hypertension and dyslipidemia. He presented with upper extremities proximal muscle and upper back moderate pain that progressed to excruciating pain with restriction of motion, weakness, and stiffness of 3 days of evolution. He denied trauma, abnormal exerci...

Introduction: Severe diabetic ketoacidosis (S-DKA) is a life-threatening condition requiring immediate hospitalization and treatment. Although mostly associated with type one diabetic patients, it is also a common condition in type two diabetes mellitus (T2DM). Our objective was to determine the main clinical and metabolic alterations associated with S-DKA in T2DM patients.Methods: We retrospectively analyzed the medical records of 27 consecutive T2DM pa...